CAS No. 776-86-3
Batch:
Purity:99.48
Chemical Structure
Check the
Isoscopoletin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 776-86-3 | |
|---|---|---|
| Molecular Formula |
C10H8O4 |
|
| Molecular Weight (MW) | 192.17 | |
| SMILES | COC1=C(C=C2C=CC(=O)OC2=C1)O |
Isoscopoletin is a naturally occurring hydroxycoumarin compound that exhibits potent antioxidant and anti-inflammatory biological activities. It modulates cellular redox homeostasis by scavenging reactive oxygen species (ROS) and inhibiting lipid peroxidation in cellular membranes. Downstream, isoscopoletin suppresses pro-inflammatory cytokine production through inhibition of the NF-κB signaling pathway, thereby protecting cells against oxidative damage and inflammation-mediated cellular injury. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(197.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
38 mg/mL
(197.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.