CAS No. 482-27-9

Batch: Purity:99.89
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Isopimpinellin Chemical Structure
Chemical Structure
Check the Isopimpinellin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 482-27-9
Molecular Formula

C13H10O5
Molecular Weight (MW) 246.22
SMILES COC1=C2C=COC2=C(C3=C1C=CC(=O)O3)OC

Biological Activity

Isopimpinellin is a naturally derived furocoumarin and potential anticarcinogenic agent that acts through the inhibition of cytochrome P450 enzymes responsible for metabolic activation of procarcinogens. By modulating cytochrome P450 activity, isopimpinellin effectively suppresses the formation of carcinogen-induced DNA adducts, leading to decreased epidermal damage and the inhibition of skin tumor initiation in preclinical models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kleiner HE, et al. Carcinogenesis. 2002;23(10):1667-75.

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Note: Technical data last updated: Sep 1, 2026.