CAS No. 498-94-2
Batch:
Purity:99
Chemical Structure
Check the
Isonipecotic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 498-94-2 | |
|---|---|---|
| Molecular Formula |
C6H11NO2
|
|
| Molecular Weight (MW) | 129.16 | |
| SMILES | C1CNCCC1C(=O)O |
Isonipecotic acid is a heterocyclic small molecule that acts as a partial agonist of the GABAA receptor. By binding to GABAA receptors, it promotes chloride ion influx through the receptor channel, leading to neuronal membrane hyperpolarization. This activation modulates GABAergic neurotransmission, downstream central nervous system signaling pathways, and inhibitory neural circuits. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 26 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.