CAS No. 55-22-1
Batch:
Purity:99.85
Chemical Structure
Check the
Isonicotinic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 55-22-1 | |
|---|---|---|
| Molecular Formula |
C6H5NO2 |
|
| Molecular Weight (MW) | 123.11 | |
| SMILES | C1=CN=CC=C1C(=O)O |
Isonicotinic acid is a pyridinecarboxylic acid derivative and a primary metabolic product of the antitubercular prodrug isoniazid. In Mycobacterium tuberculosis, isoniazid is bioactivated by the catalase-peroxidase enzyme KatG, releasing isonicotinic acid alongside active radical intermediates that disrupt mycolic acid biosynthesis. As an isomer of nicotinic acid, it serves as an important pyridine building block and metabolite involved in bacterial metabolic processing and xenobiotic biotransformation pathways. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(40.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.