CAS No. 6817-41-0
Batch:
Purity:99.94
Chemical Structure
Check the
Isoliensinine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 6817-41-0 | |
|---|---|---|
| Molecular Formula |
C37H42N2O6 |
|
| Molecular Weight (MW) | 610.74 | |
| SMILES | CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)O)O)OC |
Isoliensinine is a natural bisbenzylisoquinoline alkaloid that functions as a bioactive agent with anti-cancer, anti-inflammatory, and anti-fibrotic properties. It induces apoptosis and autophagy in cancer cells through the generation of reactive oxygen species and activation of the p38 MAPK and JNK signaling pathways while suppressing the AKT/mTOR pathway. These molecular mechanisms lead to inhibited cell proliferation, attenuated inflammatory responses, and reduced fibrotic progression in preclinical models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(163.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(163.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.