CAS No. 486-21-5
Batch:
Purity:99.95
Chemical Structure
Check the
Isofraxidin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 486-21-5 | |
|---|---|---|
| Molecular Formula |
C11H10O5 |
|
| Molecular Weight (MW) | 222.19 | |
| SMILES | COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)O |
Isofraxidin is a bioactive coumarin compound that functions as an anti-inflammatory, antioxidant, and antibacterial agent. It suppresses lipopolysaccharide-induced inflammatory responses through the inhibition of NF-kB and MAPK signaling pathways. This inhibition results in down-regulated expression of pro-inflammatory mediators and cytokines, including inducible nitric oxide synthase, cyclooxygenase-2, TNF-alpha, and IL-6, thereby attenuating inflammatory cell phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
44 mg/mL
(198.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(198.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
44 mg/mL
(198.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.