CAS No. 946075-13-4

Batch: Purity:99.67
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Isavuconazonium sulfate Chemical Structure
Chemical Structure
Check the Isavuconazonium sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 946075-13-4
Molecular Formula

C35H35F2N8O5S.HO4S
Molecular Weight (MW) 814.84
SMILES CNCC(=O)OCC1=C(N=CC=C1)N(C)C(=O)OC(C)[N+]2=C[N](CC(O)(C(C)C3=NC(=CS3)C4=CC=C(C=C4)C#N)C5=C(F)C=CC(=C5)F)N=C2.O[S]([O-])(=O)=O

Biological Activity

Isavuconazonium sulfate is an orally active water-soluble prodrug of the broad-spectrum triazole antifungal agent isavuconazole. Following cleavage by plasma esterases, active isavuconazole targets fungal lanosterol 14α-demethylase (CYP51). Inhibition of CYP51 blocks ergosterol biosynthesis, impairing fungal cell membrane integrity and function. This disruption suppresses growth and viability across opportunistic fungal pathogens, including Aspergillus and Mucorales species.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (122.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.