CAS No. 1395347-24-6
Batch:
Purity:99.40
Chemical Structure
Check the
ISA-2011B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,8S)-2-(5-chloro-1H-indol-3-yl)-6-methyl-13,15-dioxa-3,6-diazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),10,12(16)-triene-4,7-dione | |
|---|---|---|
| CAS Number | 1395347-24-6 | |
| Molecular Formula |
C22H18ClN3O4 |
|
| Molecular Weight (MW) | 423.85 | |
| InChIKey | FSEZESVJDPKRDS-UWJYYQICSA-N |
ISA-2011B is a synthetic small-molecule inhibitor of phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα). By disrupting PIP5Kα activity, ISA-2011B downregulates downstream PI3K/AKT signaling and target gene expression, suppressing cellular proliferation, survival, and invasive phenotypes. Consequently, treatment with this selective lipid kinase inhibitor exhibits marked anti-proliferative activity and effectively induces apoptosis in aggressive prostate cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(200.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.