CAS No. 2230974-62-4

Batch: Purity:98.54
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Irpagratinib Chemical Structure
Chemical Structure
Check the Irpagratinib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(3S,4S)-3-[[6-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methylazetidin-1-yl)pyrido[3,4-d]pyrimidin-2-yl]amino]oxan-4-yl]prop-2-enamide
CAS Number 2230974-62-4
Molecular Formula

C28H32F2N6O5
Molecular Weight (MW) 570.59
InChIKey PGRHEHZIRYNZDV-FUHWJXTLSA-N

Biological Activity

Irpagratinib (ABSK011) is a potent small-molecule inhibitor targeting fibroblast growth factor receptor 4 (FGFR4). By blocking the oncogenic FGF19-FGFR4 signaling axis, it effectively suppresses FGFR4 auto-phosphorylation and disrupts downstream signal transduction pathways. This targeted blockade inhibits tumor cell proliferation and strongly suppresses tumor growth, leading to tumor regression in subcutaneous xenograft models of hepatocellular carcinoma. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (175.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Zhan TA, et al. World J Gastrointest Oncol. 2025;17(9):108649.

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Note: Technical data last updated: Sep 1, 2026.