CAS No. 288628-05-7

Batch: Purity:99.97
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Irosustat (BN83495) Chemical Structure
Chemical Structure
Check the Irosustat (BN83495) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate
CAS Number 288628-05-7
Molecular Formula

C14H15NO5S
Molecular Weight (MW) 309.34
SMILES C1CCC2=C(CC1)C(=O)OC3=C2C=CC(=C3)OS(=O)(=O)N
InChIKey DSLPMJSGSBLWRE-UHFFFAOYSA-N

Ordering Information

Biological Activity

Irosustat is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor. By targeted inhibition of steroid sulfatase, it blocks the enzymatic conversion of precursor steroid sulfates, including estrone sulfate and dehydroepiandrosterone sulfate, into active estrogenic and androgenic steroids. Consequently, this suppression impairs estrogen receptor-mediated pathway activation and inhibits downstream tumor cell proliferation in hormone-dependent cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (200.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.