CAS No. 301675-24-1
Batch:
Purity:99.89
Chemical Structure
Check the
IRAK-4 protein kinase inhibitor 2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(1H-benzimidazol-2-yl)-3-nitrobenzamide | |
|---|---|---|
| CAS Number | 301675-24-1 | |
| Molecular Formula |
C14H10N4O3 |
|
| Molecular Weight (MW) | 282.25 | |
| SMILES | [O-][N+](=O)C1=CC(=CC=C1)C(=O)NC2=NC3=CC=CC=C3[NH]2 | |
| InChIKey | QPKROMNIEAEFQA-UHFFFAOYSA-N |
IRAK-protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 receptor-associated kinase-(IRAK-. By selectively inhibiting IRAK-kinase activity, the compound disrupts downstream interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) signaling pathways. This inhibition suppresses NF-kB pathway activation and decreases pro-inflammatory cytokine expression, providing a valuable functional probe for investigating inflammatory and immune-mediated cellular responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- IRAK-4 protein kinase inhibitor 2 Solubility in DMSO
- IRAK-4 protein kinase inhibitor 2 Stock Solution
- IRAK-4 protein kinase inhibitor 2 Storage
- IRAK-4 protein kinase inhibitor 2 Stability
- IRAK-4 protein kinase inhibitor 2 Molecular Weight
- IRAK-4 protein kinase inhibitor 2 SMILES
- IRAK-4 protein kinase inhibitor 2 Chemical Structure (2D and 3D)
- IRAK-4 protein kinase inhibitor 2 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.