CAS No. 331001-62-8
Batch:
Purity:99.95
Chemical Structure
Check the
IQ-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide | |
|---|---|---|
| CAS Number | 331001-62-8 | |
| Molecular Formula |
C21H22N4O2 |
|
| Molecular Weight (MW) | 362.42 | |
| SMILES | CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N | |
| InChIKey | ALJIEVIJBAJISI-UHFFFAOYSA-N |
IQ-1 is a small-molecule agent that targets the PR72/130 subunit of protein phosphatase 2A (PP2A) to block its interaction with Nkd. By preventing the PP2A/Nkd interaction, IQ-1 selectively enhances Wnt/β-catenin signaling via the coactivator CBP over p300. This targeted activity maintains mouse embryonic stem cell pluripotency in Wnt3a-treated cells, promoting Wnt/β-catenin-driven self-renewal and expansion while effectively preventing spontaneous differentiation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(198.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.