CAS No. 66985-17-9

Batch: Purity:98.88
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Ipratropium bromide monohydrate Chemical Structure
Chemical Structure
Check the Ipratropium bromide monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 66985-17-9
Molecular Formula

C20H32BrNO4
Molecular Weight (MW) 430.38
SMILES O.[Br-].CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

Ordering Information

Biological Activity

Ipratropium bromide monohydrate is a synthetic muscarinic acetylcholine receptor (mAChR) antagonist that targets M1, M2, and M3 receptor subtypes. By blocking muscarinic acetylcholine receptors in airway smooth muscle tissue, it inhibits parasympathetic cholinergic signaling and attenuates intracellular cyclic GMP accumulation. This inhibition prevents receptor-mediated smooth muscle contraction, reducing airway hyperresponsiveness and suppressing bronchoconstriction in respiratory phenotypes.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 86 mg/mL
Ethanol 86 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.