CAS No. 1346564-56-4

Batch: Purity:99.65
Check CoA
IPI-9119 Chemical Structure
Chemical Structure
Check the IPI-9119 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-(2,6-difluorophenyl)-5-oxotetrazole-1-carbonyl]-propan-2-ylamino]-3-phenoxybenzoic acid
CAS Number 1346564-56-4
Molecular Formula

C24H19F2N5O5
Molecular Weight (MW) 495.43
SMILES CC(C)N(C(=O)N1N=NN(C1=O)C2=C(F)C=CC=C2F)C3=CC=C(C=C3OC4=CC=CC=C4)C(O)=O
InChIKey VYXOFKWKPKVNID-UHFFFAOYSA-N

Ordering Information

Biological Activity

IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN). Targeting the FASN thioesterase domain induces metabolic reprogramming, suppresses androgen receptor (AR) signaling, and downregulates full-length AR and AR-V7 protein expression via endoplasmic reticulum stress. Consequently, IPI-9119 inhibits cell proliferation, suppresses castration-resistant prostate cancer xenograft growth, and enhances enzalutamide sensitivity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 33 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.