CAS No. 1425043-73-7

Batch: Purity:99.77
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IPI-3063 Chemical Structure
Chemical Structure
Check the IPI-3063 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-6-[[(1S)-1-[8-(1-methyl-6-oxo-3-pyridinyl)-1-oxo-2-propan-2-ylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile
CAS Number 1425043-73-7
Molecular Formula

C25H25N7O2
Molecular Weight (MW) 455.51
SMILES CC(C)N1C(=CC2=C(C1=O)C(=CC=C2)C3=CN(C(=O)C=C3)C)C(C)NC4=NC=NC(=C4C#N)N
InChIKey OBHAYOJCPNWKBL-HNNXBMFYSA-N

Ordering Information

Biological Activity

IPI-3063 is a potent and selective inhibitor of p110δ, demonstrating high selectivity over other class I PI3K isoforms including p110α, p110β, and p110γ. By selectively targeting the p110δ catalytic subunit of phosphoinositide 3-kinase, IPI-3063 attenuates downstream AKT/mTOR signaling pathway activation. This blockade suppresses immune cell activation and cellular proliferation, providing a valuable chemical tool for dissecting p110δ-mediated signaling functions. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.