CAS No. 931398-72-0
Batch:
Purity:99.74
Chemical Structure
Check the
IOX2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid | |
|---|---|---|
| CAS Number | 931398-72-0 | |
| Molecular Formula |
C19H16N2O5 |
|
| Molecular Weight (MW) | 352.34 | |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O | |
| InChIKey | CAOSCCRYLYQBES-UHFFFAOYSA-N |
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) that displays marked selectivity over histone demethylases including JMJD2A, JMJD2C, JMJD2E, and JMJD3, as well as factor inhibiting HIF. By inhibiting PHD2 activity, IOX2 blocks the oxygen-dependent hydroxylation and subsequent ubiquitin-mediated degradation of HIF-1α, thereby promoting HIF-1α protein stabilization and activation of downstream hypoxic gene expression pathways. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(19.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(28.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.