CAS No. 1191252-49-9
| IUPAC Name | 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide | |
|---|---|---|
| CAS Number | 1191252-49-9 | |
| Molecular Formula |
C22H15Br2N3O4 |
|
| Molecular Weight (MW) | 545.18 | |
| SMILES | C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br | |
| InChIKey | DSFNLJXHXBIKDS-UHFFFAOYSA-N |
IOWH032 is a synthetic inhibitor targeting the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Pharmacological inhibition of CFTR blocks cAMP-dependent transepithelial chloride ion secretion across intestinal epithelial cells. This reduction in transepithelial ion transport effectively suppresses fluid accumulation induced by microbial enterotoxins, establishing CFTR inhibition as a key therapeutic approach for secretory diarrhea. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.