CAS No. 56092-81-0
Batch:
Purity:99
Chemical Structure
Check the
Ionomycin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid | |
|---|---|---|
| CAS Number | 56092-81-0 | |
| Molecular Formula |
C41H72O9 |
|
| Molecular Weight (MW) | 709.01 | |
| SMILES | CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O | |
| InChIKey | PGHMRUGBZOYCAA-ADZNBVRBSA-N |
Ionomycin is a potent and selective calcium ionophore and antibiotic produced by Streptomyces conglobatus. It selectively binds and transports divalent calcium ions across biological membranes, thereby rapidly elevating intracellular calcium levels. This calcium influx stimulates downstream signaling cascades, including the activation of protein kinase C (PKC) and calcineurin pathways, which subsequently regulates cellular processes and promotes apoptosis. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(141.04 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.