CAS No. 2745060-92-6
Batch:
Purity:99.03
Chemical Structure
Check the
INX-315
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(12-oxospiro[1,3,5,10,11-pentazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-4-yl)amino]benzenesulfonamide | |
|---|---|---|
| CAS Number | 2745060-92-6 | |
| Molecular Formula |
C19H21N7O3S |
|
| Molecular Weight (MW) | 427.48 | |
| InChIKey | KGJVKYSVVOQPDL-UHFFFAOYSA-N |
INX-315 is an orally active, selective cyclin-dependent kinase 2 (CDK2) inhibitor exhibiting an ICvalue ofin a NanoBRET assay and-fold selectivity over CDKBy decreasing the phosphorylation of CDK2 substrates, INX-315 induces G1-phase cell cycle arrest and cellular senescence. Downstream, it suppresses tumor growth in xenograft mouse models in a dose-dependent manner, demonstrating preclinical activity in CCNE1-amplified cancers. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(201.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
86 mg/mL
(201.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.