CAS No. 1000403-03-1
Chemical Structure
Check the
INT-767
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium [(3R)-3-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl] sulfate | |
|---|---|---|
| CAS Number | 1000403-03-1 | |
| Molecular Formula |
C25H44O6S.Na |
|
| Molecular Weight (MW) | 495.67 | |
| InChIKey | TXIWHUPIUUZFFK-PMWRKVJASA-M |
Biological Activity
INT-767 is a dual agonist of farnesoid X receptor (FXR, EC50 = and TGR5 (EC50 =. Activation of FXR and TGR5 signaling pathways by INT-767 regulates bile acid synthesis and transport, reduces hepatic inflammation, and attenuates biliary fibrosis. Furthermore, INT-767 stimulates bile flow and biliary bicarbonate secretion, offering protective effects against liver injury in preclinical chronic cholangiopathy models. [1]
How to Prepare Stock Solution?
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Reference
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Note: Technical data last updated: Sep 1, 2026.