Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate insulin degludec for managing type 1 diabetes mellitus, type 2 diabetes mellitus, and associated conditions such as nocturnal hypoglycemia, assessing glycemic efficacy and safety relative to other insulin regimens. Sponsored by major pharmaceutical corporations and academic institutions, these investigations encompass various recruitment statuses, including completed, currently recruiting, active but not recruiting, enrolling by invitation, and terminated.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT07173712 | NOT_YET_RECRUITING | Type 2 Diabetes |
Yanbing Li |
2026-03-15 | PHASE4 |
| NCT07032688 | RECRUITING | Type 2 Diabetes |
Jiangsu HengRui Medicine Co., Ltd. |
2025-08-11 | PHASE1 |
| NCT07387003 | NOT_YET_RECRUITING | Type 2 Diabetes (T2DM) |
Gan & Lee Pharmaceuticals. |
2026-04-10 | PHASE2 |
| NCT07630233 | NOT_YET_RECRUITING | Type 2 Diabetes Mellitus (T2DM) |
The United Bio-Technology (Hengqin) Co., Ltd. |
2026-06-19 | PHASE1 |
| NCT06280703 | RECRUITING | Healthy; Type 1 Diabetes Mellitus |
Eli Lilly and Company |
2024-05-15 | PHASE1 |
| NCT07527078 | RECRUITING | Type 2 Diabetes (T2DM) |
Gan & Lee Pharmaceuticals. |
2026-04-07 | PHASE3 |
| NCT07146347 | RECRUITING | Type 2 Diabetes |
Gan and Lee Pharmaceuticals, USA |
2025-08-15 | PHASE1 |
| NCT06685185 | COMPLETED | Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2024-11-12 | PHASE1 |
| NCT07242664 | RECRUITING | Type 1 Diabetes Mellitis |
Gan and Lee Pharmaceuticals, USA |
2025-10-13 | PHASE1 |
| NCT06767748 | ACTIVE_NOT_RECRUITING | Diabetes |
Gan & Lee Pharmaceuticals. |
2025-02-15 | PHASE3 |
| NCT07018453 | ACTIVE_NOT_RECRUITING | Type 2 Diabetes Mellitus |
Jiangsu HengRui Medicine Co., Ltd. |
2025-07-16 | PHASE2 |
| NCT04955834 | UNKNOWN | Type 2 Diabetes |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
2021-07-27 | PHASE3 |
| NCT05641337 | UNKNOWN | Liver Cirrhosis; Diabetes |
Huashan Hospital |
2022-10-01 | PHASE3 |
| NCT06238778 | COMPLETED | Diabetes Mellitus, Type 1 |
Diasome Pharmaceuticals |
2023-12-28 | PHASE2 |
| NCT06559722 | UNKNOWN | Type 2 Diabetes |
Tonghua Dongbao Pharmaceutical Co.,Ltd |
2024-08 | PHASE3 |
| NCT05417841 | COMPLETED | Type 2 Diabetes Mellitus |
Beijing Hospital |
2023-03-23 | |
| NCT07599891 | COMPLETED | Glucocorticoid Induced Hyperglycemia |
Max Healthcare Insititute Limited |
2023-09-01 | PHASE4 |
| NCT06288412 | COMPLETED | Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2024-02-26 | PHASE1 |
| NCT05218915 | COMPLETED | Diabetes Mellitus; Diabetic Kidney Disease |
Elaine Chow |
2022-01-28 | PHASE4 |
| NCT05802862 | COMPLETED | Diabetes |
Sunshine Lake Pharma Co., Ltd. |
2023-07-06 | PHASE3 |
| NCT06202079 | COMPLETED | Diabetes Mellitus, Type 2 |
Gan and Lee Pharmaceuticals, USA |
2023-08-11 | PHASE2 |
| NCT06199505 | COMPLETED | Type 2 Diabetes |
Gan and Lee Pharmaceuticals, USA |
2023-11-21 | PHASE2 |
| NCT06132126 | COMPLETED | Healthy; Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2023-11-17 | PHASE1 |
| NCT06449703 | UNKNOWN | Healthy |
Tonghua Dongbao Pharmaceutical Co.,Ltd |
2024-05-06 | PHASE1 |
| NCT06178874 | COMPLETED | Glycemic Control; Insulin; Critical Illness |
Ain Shams University |
2023-12-01 | |
| NCT05275400 | COMPLETED | Type 2 Diabetes |
Eli Lilly and Company |
2022-03-08 | PHASE3 |
| NCT05463744 | COMPLETED | Type 1 Diabetes; Diabetes |
Eli Lilly and Company |
2022-08-12 | PHASE3 |
| NCT05362058 | COMPLETED | Diabetes; Type 2 Diabetes |
Eli Lilly and Company |
2022-06-03 | PHASE3 |
| NCT05904743 | COMPLETED | Diabetes Mellitus, Type 1 |
Mannkind Corporation |
2023-07-07 | PHASE4 |
| NCT04965051 | UNKNOWN | Type 1 Diabetes Mellitus With Diabetic Gastroparesis; HbA1c; Time in Range |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2021-08 | |
| NCT06553248 | COMPLETED | Diabetes |
Gan and Lee Pharmaceuticals, USA |
2023-03-22 | PHASE1 |
| NCT06199505 | Enrolling by invitation | Type 2 Diabetes |
Gan and Lee Pharmaceuticals USA |
2023-11-27 | Phase 2 |
| NCT05767255 | UNKNOWN | Diabetes Mellitus, Type 2 Treated With Insulin |
Hospital Universitario San Ignacio |
2022-12-01 | PHASE3 |
| NCT06202079 | Recruiting | Diabetes Mellitus Type 2 |
Gan and Lee Pharmaceuticals USA |
2023-08-29 | Phase 2 |
| NCT05552859 | TERMINATED | Type 2 Diabetes Mellitus; Renal Impairment |
Sanofi |
2022-12-05 | PHASE4 |
| NCT04538352 | COMPLETED | Type 2 Diabetes |
The Cleveland Clinic |
2021-01-18 | PHASE4 |
| NCT06556641 | COMPLETED | Healthy Subjects |
Gan and Lee Pharmaceuticals, USA |
2022-12-17 | PHASE1 |
| NCT04671043 | COMPLETED | Caffeine and Carbohydrate; Carbohydrate Only; Placebo |
Insel Gruppe AG, University Hospital Bern |
2022-02-04 | |
| NCT05243628 | COMPLETED | Type 1 Diabetes |
Mannkind Corporation |
2022-03-31 | PHASE4 |
| NCT04623086 | COMPLETED | Type 1 Diabetes |
University of Washington |
2020-02-14 | PHASE4 |
| NCT04760626 | COMPLETED | Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2021-03-01 | PHASE3 |
| NCT03737240 | COMPLETED | Diabetes Mellitus |
Emory University |
2019-01-15 | PHASE3 |
| NCT04588259 | COMPLETED | Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2020-10-09 | PHASE3 |
| NCT04795531 | COMPLETED | Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2021-03-24 | PHASE3 |
| NCT03862716 | COMPLETED | Type 2 Diabetes Mellitus |
Population Health Research Institute |
2019-04-23 | PHASE3 |
| NCT04663282 | COMPLETED | Type 2 Diabetes |
Jiangsu HengRui Medicine Co., Ltd. |
2021-02-04 | PHASE2 |
| NCT04848480 | COMPLETED | Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2021-04-30 | PHASE3 |
| NCT05576298 | COMPLETED | Type 2 Diabetes |
Sunshine Lake Pharma Co., Ltd. |
2021-10-08 | PHASE1 |
| NCT05036876 | COMPLETED | Type 2 Diabetes |
Medanta, The Medicity, India |
2021-10-10 | |
| NCT04770532 | COMPLETED | Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2021-03-05 | PHASE3 |
| NCT03952130 | COMPLETED | Type 1 Diabetes Mellitus |
Eli Lilly and Company |
2019-05-29 | PHASE3 |
| NCT05360537 | COMPLETED | Diabetes Mellitus, Type 2 |
University of Palermo |
2021-04-01 | PHASE4 |
| NCT04450394 | COMPLETED | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2020-07-01 | PHASE2 |
| NCT04450407 | COMPLETED | Type 1 Diabetes Mellitus |
Eli Lilly and Company |
2020-07-06 | PHASE2 |
| NCT04075513 | COMPLETED | Type 1 Diabetes Mellitus |
Sanofi |
2019-10-09 | PHASE4 |
| NCT03740919 | COMPLETED | Type 1 Diabetes Mellitus |
Eli Lilly and Company |
2019-04-07 | PHASE3 |
| NCT04569994 | COMPLETED | Healthy Volunteers; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2020-09-30 | PHASE1 |
| NCT03400501 | COMPLETED | Type 1 Diabetes Mellitus |
Yale University |
2017-10-01 | EARLY_PHASE1 |
| NCT04585776 | COMPLETED | Type 1 Diabetes |
Eli Lilly and Company |
2020-10-30 | PHASE2 |
| NCT03336528 | COMPLETED | Type 2 Diabetes |
Emory University |
2018-01-02 | PHASE4 |
| NCT03952143 | COMPLETED | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2019-05-27 | PHASE3 |
| NCT03377699 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2017-11-22 | PHASE3 |
| NCT03882970 | COMPLETED | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2019-04-01 | PHASE3 |
| NCT04276428 | COMPLETED | Diabetes Mellitus, Type 2 |
Eli Lilly and Company |
2020-02-28 | PHASE1 |
| NCT03987191 | COMPLETED | Type 1 Diabetes |
University of Colorado, Denver |
2020-01-10 | PHASE4 |
| NCT03668808 | COMPLETED | Diabetes Mellitus, Type 1 |
Sansum Diabetes Research Institute |
2018-11-16 | PHASE4 |
| NCT04409587 | COMPLETED | Type1 Diabetes Mellitus |
Mountain Diabetes and Endocrine Center |
2018-04-12 | PHASE4 |
| NCT03736785 | COMPLETED | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2018-11-15 | PHASE2 |
| NCT03387787 | COMPLETED | Type 2 Diabetes Mellitus |
Insel Gruppe AG, University Hospital Bern |
2018-01-30 | PHASE2; PHASE3 |
| NCT03687827 | COMPLETED | Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2018-10-02 | PHASE4 |
| NCT03938740 | COMPLETED | Diabetes Mellitus, Type 1 |
Diasome Pharmaceuticals |
2019-03-18 | PHASE2 |
| NCT04190160 | COMPLETED | Type2 Diabetes |
Stefano Rizza |
2018-11-19 | |
| NCT03726125 | COMPLETED | Healthy |
Eli Lilly and Company |
2018-11-20 | PHASE1 |
| NCT03497260 | COMPLETED | Type 1 Diabetes Mellitus; Diabetes Complications |
Insel Gruppe AG, University Hospital Bern |
2019-01-04 | |
| NCT03091712 | COMPLETED | Type 2 Diabetes Mellitus |
Glooko |
2017-05-05 | |
| NCT04692415 | COMPLETED | Diabetes Mellitus, Type 2 |
University of Split, School of Medicine |
2018-12-15 | PHASE4 |
| NCT03172494 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2017-05-26 | PHASE3 |
| NCT03838783 | UNKNOWN | Type 1 Diabetes Mellitus |
LMC Diabetes & Endocrinology Ltd. |
2018-05-15 | PHASE4 |
| NCT03175120 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2017-05-26 | PHASE3 |
| NCT02192450 | COMPLETED | Type 1 Diabetes Mellitus; Nocturnal Hypoglycemia; Recurrent Severe Hypoglycaemia |
Nordsjaellands Hospital |
2015-01 | PHASE4 |
| NCT03078478 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2017-03-13 | PHASE3 |
| NCT04664764 | Unknown status | Type 1 Diabetes Mellitus With Hypoglycemia|type1diabetes |
Ain Shams University |
2019-02-21 | Phase 4 |
| NCT03001323 | TERMINATED | Diabetes Mellitus |
Hennepin Healthcare Research Institute |
2017-01 | |
| NCT03268005 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2017-09-19 | PHASE3 |
| NCT03736785 | Completed | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2018-11-15 | Phase 2 |
| NCT02501161 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-01-31 | PHASE3 |
| NCT03674866 | Completed | Diabetes Mellitus Type 1|Diabetes Mellitus Type 2 |
Novo Nordisk A/S |
2018-10-29 | -- |
| NCT03214367 | COMPLETED | Type 1 Diabetes Mellitus |
Eli Lilly and Company |
2017-07-17 | PHASE3 |
| NCT03214380 | COMPLETED | Type 2 Diabetes Mellitus |
Eli Lilly and Company |
2017-07-14 | PHASE3 |
| NCT03349840 | TERMINATED | Type2 Diabetes |
Weill Cornell Medical College in Qatar |
2018-01-07 | PHASE4 |
| NCT03244241 | UNKNOWN | Type 2 Diabetes Mellitus |
Merete Bechmann Christensen |
2017-04-01 | PHASE4 |
| NCT02670915 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2016-05-04 | PHASE3 |
| NCT03292185 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2017-09-29 | PHASE1 |
| NCT03349840 | Terminated | Type2 Diabetes |
Weill Cornell Medical College in Qatar|Novo Nordisk A/S |
2018-01-07 | Phase 4 |
| NCT02607306 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2015-11-18 | PHASE3 |
| NCT02964104 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-11-15 | PHASE1 |
| NCT02911948 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-09-21 | PHASE3 |
| NCT02967211 | COMPLETED | Diabetes Mellitus, Type 2 |
Sanofi |
2015-12-21 | PHASE4 |
| NCT02967224 | COMPLETED | Diabetes Mellitus, Type 2 |
Sanofi |
2015-11-05 | PHASE4 |
| NCT02773368 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-05-23 | PHASE3 |
| NCT02906917 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-09-20 | PHASE3 |
| NCT02738151 | COMPLETED | Diabetes Mellitus, Type 2 |
Sanofi |
2016-05-19 | PHASE4 |
| NCT02500706 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2016-05-04 | PHASE3 |
| NCT02762578 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-05-03 | PHASE3 |
| NCT01959529 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-10-29 | PHASE3 |
| NCT02420262 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2015-07-26 | PHASE3 |
| NCT02844790 | COMPLETED | Healthy |
Novo Nordisk A/S |
2016-07-26 | PHASE1 |
| NCT02648217 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2016-01-04 | PHASE3 |
| NCT02536859 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2015-08-31 | PHASE1 |
| NCT02034513 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2014-01-05 | PHASE3 |
| NCT02298192 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2014-11-21 | PHASE3 |
| NCT02030600 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2014-01-06 | PHASE3 |
| NCT02680457 | COMPLETED | Type 2 Diabetes Mellitus |
University of Guadalajara |
2013-11 | PHASE4 |
| NCT02148861 | COMPLETED | Diabetes; Type 2 Diabetes Mellitus |
Novo Nordisk A/S |
2014-05-26 | PHASE1 |
| NCT02100475 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2014-04 | PHASE3 |
| NCT01835431 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2013-10-17 | PHASE3 |
| NCT01952145 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-09-20 | PHASE3 |
| NCT01849289 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-06-02 | PHASE3 |
| NCT01880736 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-06 | PHASE3 |
| NCT01676116 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-08-29 | PHASE3 |
| NCT01814137 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-03 | PHASE3 |
| NCT01713530 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2013-02-21 | PHASE3 |
| NCT01570751 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-04 | PHASE3 |
| NCT01664247 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-10-01 | PHASE3 |
| NCT01916174 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2; Healthy |
Novo Nordisk A/S |
2013-08 | PHASE1 |
| NCT01618162 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-08-29 | PHASE3 |
| NCT01680341 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-08-31 | PHASE3 |
| NCT01773798 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2013-01 | PHASE1 |
| NCT01513473 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2012-01-16 | PHASE3 |
| NCT01704417 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2012-10 | PHASE1 |
| NCT01513590 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2012-01-16 | PHASE3 |
| NCT01569841 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2012-04 | PHASE3 |
| NCT01392573 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-11-28 | PHASE3 |
| NCT01623375 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2012-06 | PHASE1 |
| NCT01388361 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-09 | PHASE3 |
| NCT01590836 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2012-04 | PHASE1 |
| NCT01336023 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-05-23 | PHASE3 |
| NCT01365507 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-06 | PHASE3 |
| NCT01364428 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-06 | PHASE3 |
| NCT01455142 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2011-10 | PHASE1 |
| NCT01326026 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-03 | PHASE3 |
| NCT01467414 | TERMINATED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-10 | PHASE1 |
| NCT01437592 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2011-09-06 | PHASE1 |
| NCT01272193 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2011-01 | PHASE3 |
| NCT01319240 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2011-03 | PHASE1 |
| NCT01059812 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-02-01 | PHASE3 |
| NCT01059799 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-02-01 | PHASE3 |
| NCT00982644 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2009-09 | PHASE3 |
| NCT01074268 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-02 | PHASE3 |
| NCT01076647 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-03 | PHASE3 |
| NCT00982228 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-09-01 | PHASE3 |
| NCT01068678 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-02 | PHASE3 |
| NCT01174303 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-08 | PHASE1 |
| NCT01068665 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-03 | PHASE3 |
| NCT01138488 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-06 | PHASE1 |
| NCT01079234 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-03 | PHASE3 |
| NCT01154881 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-06 | PHASE1 |
| NCT01193387 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2010-08 | PHASE1 |
| NCT01046110 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-01 | PHASE3 |
| NCT01134224 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-05 | PHASE1 |
| NCT01173926 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-07 | PHASE1 |
| NCT01135992 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-06 | PHASE3 |
| NCT00972283 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2009-09-01 | PHASE3 |
| NCT01151072 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2010-06 | PHASE1 |
| NCT01135927 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-06 | PHASE1 |
| NCT01043510 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-01 | PHASE1 |
| NCT01045447 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-01 | PHASE3 |
| NCT01045707 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2010-01 | PHASE3 |
| NCT01006291 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2009-11 | PHASE3 |
| NCT01009580 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2009-11-05 | PHASE3 |
| NCT01114542 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-05-03 | PHASE1 |
| NCT01125553 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2010-05 | PHASE1 |
| NCT01076634 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-02 | PHASE1 |
| NCT01030926 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-12 | PHASE1 |
| NCT00978627 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-08 | PHASE3 |
| NCT01006057 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2009-11 | PHASE1 |
| NCT01051102 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2010-01 | PHASE1 |
| NCT01002768 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-10 | PHASE1 |
| NCT00976326 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2009-08 | PHASE1 |
| NCT00992537 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-10 | PHASE1 |
| NCT00993096 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-09 | PHASE1 |
| NCT00983021 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2009-09 | PHASE1 |
| NCT00964418 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-08 | PHASE1 |
| NCT00961324 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-07-27 | PHASE1 |
| NCT00966368 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2009-08 | PHASE1 |
| NCT00964964 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-08 | PHASE1 |
| NCT00842361 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2009-01 | PHASE2 |
| NCT00841087 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2009-01 | PHASE2 |
| NCT01868568 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2008-04 | PHASE1 |
| NCT00611884 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2008-01 | PHASE2 |
| NCT00613951 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2008-01 | PHASE2 |
| NCT01868581 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2008-05 | PHASE1 |
| NCT00614055 | COMPLETED | Diabetes; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2008-01 | PHASE2 |
| NCT00612040 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2008-01 | PHASE2 |
| NCT01868529 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2008-01 | PHASE1 |
| NCT01868555 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2007-12 | PHASE1 |
| NCT01865331 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2006-12 | PHASE1 |
| NCT01865305 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2006-09 | PHASE1 |
| NCT01865318 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1 |
Novo Nordisk A/S |
2006-09 | PHASE1 |
| NCT01865292 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2006-08 | PHASE1 |
| NCT01865279 | COMPLETED | Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 |
Novo Nordisk A/S |
2005-12 | PHASE1 |
(data from https://clinicaltrials.gov, updated on 2026-02-06)
Check the
Insulin Degludec
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.