CAS No. 1001753-24-7
Batch:
Purity:99.95
Chemical Structure
Check the
INH6
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide | |
|---|---|---|
| CAS Number | 1001753-24-7 | |
| Molecular Formula |
C19H18N2OS |
|
| Molecular Weight (MW) | 322.42 | |
| SMILES | CC1=CC(=C(C(=C1)C)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C | |
| InChIKey | WCZLNJTXHZPHLM-UHFFFAOYSA-N |
Biological Activity
INH6 is a potent small-molecule Hec1 inhibitor that specifically disrupts the interaction between Hec1 and Nek2 protein kinase. By targeting the Hec1/Nek2 pathway, INH6 impairs kinetochore-microtubule attachment, causing severe chromosome mis-alignment and spindle assembly defects during mitosis. This targeted disruption leads to mitotic arrest, inhibition of cellular proliferation, and apoptosis in sensitive cancer cell lines.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(198.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.