CAS No. 200134-22-1

Batch: Purity:99.00
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INH14 Chemical Structure
Chemical Structure
Check the INH14 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(4-ethylphenyl)-3-phenylurea
CAS Number 200134-22-1
Molecular Formula

C15H16N2O
Molecular Weight (MW) 240.30
SMILES CCC1=CC=C(C=C1)NC(=O)NC2=CC=CC=C2
InChIKey CPCZNJSFVOOZOG-UHFFFAOYSA-N

Biological Activity

INH14 is a small-molecule inhibitor targeting TLR2-mediated NF-κB activation through selective action on IKKα and IKKβ. By blocking the catalytic subunits of the IκB kinase complex, INH14 inhibits IκBα phosphorylation and subsequent nuclear translocation of the p65/p50 NF-κB dimer. This signaling pathway disruption downregulates TLR2-driven pro-inflammatory cascades, leading to reduced expression of downstream inflammatory cytokines and cell survival phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Karin M, et al. Annu Rev Immunol. 2000;18:621-63.

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Note: Technical data last updated: Sep 1, 2026.