CAS No. 1310746-10-1

Batch: Purity:99.04
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Infigratinib Phosphate Chemical Structure
Chemical Structure
Check the Infigratinib Phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea;phosphoric acid
CAS Number 1310746-10-1
Molecular Formula

C26H31Cl2N7O3.H3O4P
Molecular Weight (MW) 658.47
InChIKey GUQNHCGYHLSITB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Infigratinib Phosphate is an orally bioavailable pan-inhibitor of fibroblast growth factor receptors, targeting FGFR1 (IC50 =, FGFR2 (IC50 =, FGFR3 (IC50 = 1 nM), and FGFR4 (IC50 =. By blocking receptor autophosphorylation, it impairs downstream MAPK and AKT signaling pathways, thereby inhibiting cell proliferation, inducing apoptosis, and suppressing angiogenesis and tumor growth in FGFR-dependent cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (151.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.