CAS No. 63610-08-2
Batch:
Purity:99.85
Chemical Structure
Check the
Indobufen
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]butanoic acid | |
|---|---|---|
| CAS Number | 63610-08-2 | |
| Molecular Formula |
C18H17NO3 |
|
| Molecular Weight (MW) | 295.33 | |
| SMILES | CCC(C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O)C(=O)O | |
| InChIKey | AYDXAULLCROVIT-UHFFFAOYSA-N |
Indobufen is a reversible inhibitor of platelet cyclooxygenase (COX), specifically targeting COX-1 to suppress thromboxane synthesis. By blocking the COX-1-mediated conversion of arachidonic acid into thromboxane A2, indobufen disrupts downstream signaling pathways required for platelet activation and aggregation. This reversible targeted suppression diminishes pro-thrombotic activity and reduces thrombus formation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.