CAS No. 753498-25-8

Batch: Purity:99.88
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Indacaterol Maleate Chemical Structure
Chemical Structure
Check the Indacaterol Maleate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (Z)-but-2-enedioic acid;5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one
CAS Number 753498-25-8
Molecular Formula

C24H28N2O3.C4H4O4
Molecular Weight (MW) 508.56
SMILES CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O
InChIKey IREJFXIHXRZFER-PCBAQXHCSA-N

Biological Activity

Indacaterol Maleate is a potent, ultra-long-acting β-adrenoceptor agonist that selectively targets β2-adrenergic receptors. Upon binding, it stimulates intracellular cyclic adenosine monophosphate (cAMP) accumulation through adenylate cyclase activation, leading to effective relaxation of airway smooth muscle tissue. This signaling pathway downregulates smooth muscle tone and mediates sustained bronchodilatory responses in pulmonary cell models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 102 mg/mL (200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Battram C, et al. J Pharmacol Exp Ther. 2006;317(2):762-70.

[2] Naline E, et al. Eur Respir J. 2007;29(3):575-81.

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Note: Technical data last updated: Sep 1, 2026.