CAS No. 2230911-59-6

Batch: Purity:99.72
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INCB086550 Chemical Structure
Chemical Structure
Check the INCB086550 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R)-1-[[7-cyano-2-[3-[3-[[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-1,7-naphthyridin-8-yl]amino]-2-methylphenyl]-2-methylphenyl]-1,3-benzoxazol-5-yl]methyl]pyrrolidine-3-carboxylic acid
CAS Number 2230911-59-6
Molecular Formula

C41H39N7O4
Molecular Weight (MW) 693.79
InChIKey QARLNMDDSQMINK-BVRKHOPBSA-N

Biological Activity

INCB086550 is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 ≤. By binding directly to PD-L1, it blocks the engagement of PD-1 and promotes PD-L1 dimerization and internalization. Inhibition of this signaling axis restores T-cell receptor activation, enhances cytotoxic T-lymphocyte function, and reactivates antitumor immune responses within the tumor microenvironment. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (144.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Zak KM, et al. Structure. 2017;25(8):1163-1174.

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Note: Technical data last updated: Sep 1, 2026.