CAS No. 1820889-23-3

Batch: Purity:99.06
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INCB057643 Chemical Structure
Chemical Structure
Check the INCB057643 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,2,4-trimethyl-8-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-methylsulfonyl-1,4-benzoxazin-3-one
CAS Number 1820889-23-3
Molecular Formula

C20H21N3O5S
Molecular Weight (MW) 415.46
SMILES CC1(C(=O)N(C2=CC(=CC(=C2O1)C3=CN(C(=O)C4=C3C=CN4)C)S(=O)(=O)C)C)C
InChIKey VZSAMEOETVNDQH-UHFFFAOYSA-N

Ordering Information

Biological Activity

INCB057643 is a bromodomain and extra-terminal (BET) protein inhibitor that targets the acetylated lysine recognition motifs within BET bromodomains. By competitive binding, it prevents the interaction between BET proteins and acetylated lysines on chromatin histones. Disruption of this epigenetic reader function downregulates key transcriptional programs including the MYC pathway, ultimately suppressing cell proliferation and oncogenic gene expression profiles. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.