CAS No. 941685-27-4
Batch:
Purity:98
Chemical Structure
Check the
INCB032304
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 941685-27-4 | |
|---|---|---|
| Molecular Formula |
C15H21N5OSi |
|
| Molecular Weight (MW) | 315.45 | |
| SMILES | C[Si](C)(C)CCOCN1C=CC2=C(N=CN=C21)C3=CNN=C3 |
INCB032304 is a pharmaceutical intermediate and precursor used in the synthesis of Janus kinase (JAK) inhibitors, including ruxolitinib. These agents target Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2), leading to the suppression of downstream JAK/STAT signaling pathways. Blockade of this pathway regulates cytokine signaling, cellular proliferation, and survival in preclinical models of myeloproliferative disorders. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(199.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.