CAS No. 3519-82-2
Batch:
Purity:99.15
Chemical Structure
Check the
INCA-6
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3519-82-2 | |
|---|---|---|
| Molecular Formula |
C20H12O2 |
|
| Molecular Weight (MW) | 284.31 |
INCA-6 is a cell-permeable inhibitor of nuclear factor of activated T-cells (NFAT) signaling. It selectively blocks the docking of phosphorylated NFAT to calcineurin, thereby preventing calcineurin-dependent NFAT dephosphorylation and downstream calcineurin-NFAT signaling. By impairing calcineurin-NFAT complex formation, INCA-6 selectively suppresses NFAT-mediated gene transcription and downstream cellular responses without inhibiting calcineurin phosphatase activity toward other substrates. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
19 mg/mL
(66.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.