CAS No. 2446816-88-0
Batch:
Purity:99.68
Chemical Structure
Check the
Inaxaplin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide | |
|---|---|---|
| CAS Number | 2446816-88-0 | |
| Molecular Formula |
C21H18F3N3O3 |
|
| Molecular Weight (MW) | 417.38 | |
| InChIKey | CTXLPYZCBOVVQK-UZLBHIALSA-N |
Biological Activity
Inaxaplin (VX-147) is an orally active inhibitor of apolipoprotein L1 (APOL1) function. By inhibiting APOL1-mediated channel activity and monovalent cation flux, inaxaplin attenuates aberrant GPCR and IPsignaling, restores intracellular calcium balance, and protects mitochondrial function. These cellular effects mitigate podocyte injury and reduce proteinuria in experimental models of APOL1-associated kidney disease. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(198.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(198.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
- Inaxaplin Mechanism of Action: APOL1 Inhibition in Podocyte Research
- Inaxaplin Clinical Trials
- Inaxaplin Working Concentration | Cell Culture | Treatment
- Inaxaplin Solubility in DMSO
- Inaxaplin Stock Solution
- Inaxaplin Storage
- Inaxaplin Stability
- Inaxaplin Combination Database
- Inaxaplin Molecular Weight
- Inaxaplin Chemical Structure (2D and 3D)
- Inaxaplin IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.