CAS No. 662163-81-7

Batch: Purity:99.99
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Importazole Chemical Structure
Chemical Structure
Check the Importazole product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(1-phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine
CAS Number 662163-81-7
Molecular Formula

C20H22N4
Molecular Weight (MW) 318.42
SMILES CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCCC4
InChIKey HKGJEZIGDHFJFL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Importazole is a small-molecule inhibitor of the transport receptor importin-beta (Karyopherin beta) that specifically blocks importin-beta–mediated nuclear protein transport. By selectively impairing the nuclear import of key cargo proteins, Importazole disrupts nucleocytoplasmic trafficking pathways. This targeted inhibition subsequently halts cell cycle progression, triggers apoptotic signal transduction, and effectively suppresses tumor cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (197.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.