CAS No. 2408840-26-4
Batch:
Purity:96.07
Chemical Structure
Check the
Imlunestrant
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5R)-5-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol | |
|---|---|---|
| CAS Number | 2408840-26-4 | |
| Molecular Formula |
C29H24F4N2O3 |
|
| Molecular Weight (MW) | 524.51 | |
| InChIKey | UVBQMXOKKDCBJN-MUUNZHRXSA-N |
Imlunestrant (LY is a potent, orally bioavailable selective estrogen receptor degrader (SERD) that functions as a pure antagonist of estrogen receptor alpha (ERα). It promotes effective degradation of both wild-type and mutant ERα, leading to the inhibition of ER-dependent target gene expression. Consequently, imlunestrant induces cell cycle arrest and suppresses cell proliferation, resulting in sustained inhibition of estrogen-driven tumor growth in ER-positive models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(190.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.