CAS No. 99011-78-6
Batch:
Purity:99.90
Chemical Structure
Check the
Imiquimod hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 99011-78-6 | |
|---|---|---|
| Molecular Formula |
C14H16N4.ClH |
|
| Molecular Weight (MW) | 276.77 |
Imiquimod hydrochloride is a small-molecule immune response modifier that acts as a potent agonist of toll-like receptor 7 (TLR7). Activation of TLR7 engages MyD88-dependent signaling pathways, promoting the activation of NF-kB and the subsequent production of pro-inflammatory cytokines and antiviral proteins. These downstream cellular responses mediate robust antitumoral and antiviral efficacy against viral infections and cutaneous malignancies. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(18.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.