CAS No. 1990504-34-1
Batch:
Purity:99.00
Chemical Structure
Check the
Bomedemstat (IMG-7289)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(2S)-5-[[(1R,2S)-2-(4-fluorophenyl)cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]-4-(triazol-1-yl)benzamide | |
|---|---|---|
| CAS Number | 1990504-34-1 | |
| Molecular Formula |
C28H34FN7O2 |
|
| Molecular Weight (MW) | 519.61 | |
| InChIKey | KQKBMHGOHXOHTD-KKUQBAQOSA-N |
Biological Activity
Bomedemstat (IMG-7289) is an orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1). By blocking LSD1 activity, it increases global methylation levels of histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), resulting in altered gene expression profiles. These epigenetic modifications lead to the inhibition of cancer cell proliferation and the induction of apoptosis, exhibiting potent anti-cancer activity. [1][2]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(192.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
- Bomedemstat (IMG-7289) Mechanism of Action: LSD1 Inhibition in Megakaryocyte Research
- Bomedemstat (IMG-7289) Clinical Trials
- Bomedemstat (IMG-7289) Working Concentration | Cell Culture | Treatment
- Bomedemstat (IMG-7289) Solubility in DMSO
- Bomedemstat (IMG-7289) Storage
- Bomedemstat (IMG-7289) Stability
- Bomedemstat (IMG-7289) Molecular Weight
- Bomedemstat (IMG-7289) Chemical Structure (2D and 3D)
- Bomedemstat (IMG-7289) IC50 for Cell-based and Cell-free Assays
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- Bomedemstat (IMG-7289) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.