CAS No. 881970-80-5
Batch:
Purity:97.62
Chemical Structure
Check the
iMDK
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl]chromen-2-one | |
|---|---|---|
| CAS Number | 881970-80-5 | |
| Molecular Formula |
C21H13FN2O2S |
|
| Molecular Weight (MW) | 376.41 | |
| InChIKey | IWFKQTWYILKFGE-UHFFFAOYSA-N |
Biological Activity
iMDK is a small-molecule inhibitor targeting phosphatidylinositol 3-kinase (PI3K) and the growth factor midkine (MDK). Inhibition of MDK downregulates PI3K/AKT signaling, thereby suppressing proliferation and inducing apoptosis in non-small cell lung cancer (NSCLC) cells. Furthermore, iMDK cooperates with MEK inhibitors to attenuate tumorigenesis in KRAS-mutant and squamous NSCLC models while displaying minimal toxicity to normal human cells.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(13.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.