CAS No. 439144-66-8
Batch:
Purity:99.72
Chemical Structure
Check the
IMD-0560
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide | |
|---|---|---|
| CAS Number | 439144-66-8 | |
| Molecular Formula |
C15H8BrF6NO2 |
|
| Molecular Weight (MW) | 428.12 | |
| SMILES | OC1=CC=C(Br)C=C1C(=O)NC2=CC(=CC=C2C(F)(F)F)C(F)(F)F | |
| InChIKey | SVGRIJCSKWXOPA-UHFFFAOYSA-N |
IMD-0560 is a targeted inhibitor of IκB kinase (IKK), specifically targeting the IKKβ subunit. Treatment suppresses TNFα-induced phosphorylation of IκBα and nuclear translocation of NF-kB, downregulating downstream inflammatory pathways. In cellular models, IMD-0560 inhibits the proliferation of rheumatoid fibroblast-like synoviocytes and suppresses the production of inflammatory cytokines, including IL-6, IL-8, and MCP-1. Furthermore, inhibition of IKKβ by IMD-0560 attenuates tumor cell invasion and bone invasion in cancer models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.