CAS No. 6975-75-3
Batch:
Purity:99.68
Chemical Structure
Check the
ILK-IN-3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine | |
|---|---|---|
| CAS Number | 6975-75-3 | |
| Molecular Formula |
C10H12N6O |
|
| Molecular Weight (MW) | 232.24 | |
| SMILES | COC1=CC=C(C=C1)N=NC2=C(N)[NH]N=C2N | |
| InChIKey | QNRNTYHAOBVOKW-UHFFFAOYSA-N |
ILK-IN-is a small-molecule inhibitor of integrin-linked kinase (ILK) with antitumor activity. By inhibiting ILK activity, ILK-IN-suppresses downstream AKT phosphorylation within the AKT signaling pathway, leading to reduced vascular endothelial growth factor (VEGF) secretion. These pathway disruptions alter F-actin cytoarchitecture, inhibit tumor cell growth, and promote apoptosis and anti-angiogenic effects in cancer cells. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(198.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.