CAS No. 123663-49-0
Batch:
Purity:99.99
Chemical Structure
Check the
Iguratimod
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 123663-49-0 | |
|---|---|---|
| Molecular Formula |
C17H14N2O6S |
|
| Molecular Weight (MW) | 374.37 | |
| SMILES | CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3 |
Iguratimod (T-614) is a small-molecule disease-modifying antirheumatic agent with potent anti-inflammatory and immunomodulatory activities. It suppresses the activation of NF-kB signaling and cyclooxygenase-2 (COX-2) expression, thereby inhibiting the production of key pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, iguratimod inhibits B-cell differentiation and immunoglobulin secretion, resulting in decreased inflammatory responses and attenuation of immune-mediated joint damage.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(133.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.