CAS No. 1227948-82-4

Batch: Purity:99.35
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Ifebemtinib (IN10018, BI-853520) Chemical Structure
Chemical Structure
Check the Ifebemtinib (IN10018, BI-853520) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-fluoro-5-methoxy-4-[[4-[(2-methyl-3-oxo-1H-isoindol-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-N-(1-methylpiperidin-4-yl)benzamide
CAS Number 1227948-82-4
Molecular Formula

C28H28F4N6O4
Molecular Weight (MW) 588.55
InChIKey ULMMVBPTWVRPSI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ifebemtinib (IN, BI-853520) is a potent and highly selective inhibitor of focal adhesion kinase (FAK) that inhibits FAK autophosphorylation with an IC50 of 1 nM. Blockade of FAK signaling disrupts downstream oncogenic pathways, resulting in suppressed cell motility and anchorage-independent cell proliferation. Consequently, ifebemtinib inhibits spheroid formation and attenuates orthotopic tumor growth in preclinical models of malignant pleural mesothelioma. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (169.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.