CAS No. 914638-30-5

Batch: Purity:99.91
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IDO-IN-1 Chemical Structure
Chemical Structure
Check the IDO-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number 914638-30-5
Molecular Formula

C9H7BrFN5O2
Molecular Weight (MW) 316.09
SMILES C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Br)F
InChIKey ORHZJUSHZUCMKR-UHFFFAOYSA-N

Ordering Information

Biological Activity

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor that targets the enzymatic degradation of tryptophan along the kynurenine pathway. By blocking IDO activity, this compound prevents tryptophan depletion and reduces kynurenine production in the local microenvironment. Consequently, IDO inhibition restores T-cell proliferation and effector function while suppressing regulatory T-cell differentiation, thereby reversing tumor-mediated immunosuppression and modulating anti-tumor immune responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 63 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.