CAS No. 1421936-85-7
Batch:
Purity:98.96
Chemical Structure
Check the
Iclepertin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [5-methylsulfonyl-2-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone | |
|---|---|---|
| CAS Number | 1421936-85-7 | |
| Molecular Formula |
C20H18F6N2O5S |
|
| Molecular Weight (MW) | 512.42 | |
| InChIKey | MYHDQTVHHMSLEF-DDBGAENHSA-N |
Biological Activity
Iclepertin (BI-425809) is a potent and selective small-molecule inhibitor of glycine transporter 1 (GlyT1). By inhibiting GlyT1-mediated glycine reuptake, it elevates extracellular glycine levels in the central nervous system and cerebrospinal fluid. This increase promotes N-methyl-D-aspartate (NMDA) receptor activity via enhanced co-agonist site occupancy, facilitating downstream long-term potentiation, synaptic plasticity, and cognitive function. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.