CAS No. 582323-16-8
Batch:
Purity:99.87
Chemical Structure
Check the
ICA 069673
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 582323-16-8 | |
|---|---|---|
| Molecular Formula |
C11H6ClF2N3O |
|
| Molecular Weight (MW) | 269.63 | |
| SMILES | C1=CC(=C(C=C1C(=O)NC2=CN=C(N=C2)Cl)F)F |
ICA 069673 is an orally active, potent, and selective KCNQ2/Q3 potassium channel activator. By enhancing voltage-gated KCNQ2/Q3 (Kv7.2/Kv7.3) channel activity, it promotes transmembrane potassium efflux to hyperpolarize neuronal membranes. This mechanism reduces membrane resistance, suppresses repetitive action potential generation, and dampens neuronal hyperexcitability within central nervous system pathways to modulate synaptic transmission and network excitability. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 54 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.