CAS No. 325457-99-6
Batch:
Purity:99.69
Chemical Structure
Check the
ICA-110381
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 325457-99-6 | |
|---|---|---|
| Molecular Formula |
C12H8Cl2N2O |
|
| Molecular Weight (MW) | 267.11 | |
| SMILES | C1=CC(=CC=C1C(=O)NC2=CN=C(C=C2)Cl)Cl |
ICA-110381 is a voltage-gated potassium channel modulator that acts as a KCNQ2/Q3 channel opener and a selective KCNQ1 antagonist. By activating KCNQ2/Q3-mediated M-currents, ICA-110381 enhances membrane hyperpolarization and dampens neuronal hyperexcitability. This modulation of voltage-gated potassium currents regulates neuronal signaling pathways, leading to suppressed seizure activity and reduced neuronal firing in preclinical models of epilepsy. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(198.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
53 mg/mL
(198.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.