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Ibrutinib (PCI-32765) SDS | MSDS
1.PRODUCT AND COMPANY IDENTIFICATION
Product identifier
- Product Name: Ibrutinib (PCI-32765)
- Catalog Number: S2680
- CAS Number: 936563-96-1
- IUPAC Name: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company : Selleck Chemicals
- TollFree : +1 877 796-6397
- Tel : +1 832 582-8158
- Fax : +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [GHS/CLP]:
- Acute Toxicity, oral - Category 4
- Skin Corrosion/Irritation - Category 2
- Serious eye damage/eye irritation - Category 2
- Specific Target Organ Toxicity, SE, respiratory tract irritation - Category 3
2.2 Label elements
Labeling according to Regulation (EC) No 1272/2008 [CLP]
Signal word: Warning
Hazard statement(s):
- H302: Harmful if swallowed
- H315: Causes skin irritation
- H319: Causes serious eye irritation
- H335: May cause respiratory irritation
Precautionary statement(s):
- P260: Do not breathe powder
- P264: Wash hands thoroughly after handling
- P280: Wear protective gloves/protective clothing/eye protection/face protection
- P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
- P302+352: IF ON SKIN: Wash with soap and water
- P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338: IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do so - continue rinsing
- P333+313: If skin irritation or a rash occurs: Get medical advice/attention
2.3 Other hazards
None.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
- Product Name: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
- Formula: C25 H24 N6 O2
- Molecular Weight: 440.5
- CAS Number: 936563-96-1
4. FIRST AID MEASURES
4.1 Description of first aid measures
- General advice: Consult a doctor and show this safety data sheet.
- If inhaled: Remove to fresh air and monitor breathing. If breathing becomes difficult, give oxygen. If breathing stops, give artificial respiration. Consult a doctor.
- In case of skin contact: Immediately wash skin with copious amounts of soap and water for at least 15 minutes. Remove contaminated clothing and shoes and wash before reuse. Consult a doctor.
- In case of eye contact: Flush with copious amounts of water for at least 15 minutes. Consult a doctor.
- If swallowed: Rinse mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Consult a doctor.
4.2 Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly investigated.
4.3 Indication of immediate medical attention and special treatment needed
Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.
5. FIRE-FIGHTING MEASURES
5.1 Extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
In combustion, may emit toxic fumes.
5.3 Precautions for fire-fighters
Wear suitable protective clothing to prevent contact with skin and eyes and self-contained breathing apparatus.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Do not take action without suitable protective clothing - see section 8 of SDS. Evacuate personnel to safe areas. Ensure adequate ventilation. Avoid breathing powder.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover spillage with suitable absorbent material. Sweep up material and place in an appropriate container. Hold all material for appropriate disposal as described under section 13 of SDS.
6.4 Reference to other sections
For required PPE see section 8. For disposal see section 13.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of powder. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool, well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use. Recommended storage temperature: Store at -20°C.
7.3 Specific end uses
Use in a laboratory fume hood where possible. Refer to employer's COSHH risk assessment.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
- Appropriate engineering controls: Use in a fume hood where applicable. Ensure all engineering measures described under section 7 of SDS are in place. Ensure laboratory is equipped with a safety shower and eye wash station.
- Eye/face protection: Use appropriate safety glasses.
- Skin protection: Use appropriate chemical resistant gloves (minimum requirement use standard BS EN 374:2003). Gloves should be inspected before use. Wash and dry hands thoroughly after handling.
- Body protection: Wear appropriate protective clothing.
- Respiratory protection: If risk assessment indicates necessary, use a suitable respirator.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
- Appearance: White powder
- Odor: N/A
- Odor threshold: N/A
- pH: N/A
- Melting / freezing point: N/A
- Boiling point / range: N/A
- Flash point: N/A
- Evaporation rate: N/A
- Flammability (powder): N/A
- Upper / lower flammability or explosive limits: N/A
- Vapor pressure: N/A
- Vapor density: N/A
- Relative density: N/A
- Solubility(ies): Soluble to 100 mM in DMSO
- Partition coefficient: N/A
- Auto-ignition temperature: N/A
- Decomposition temperature: N/A
- Viscosity: N/A
- Explosive properties: N/A
- Oxidising properties: N/A
9.2 Other safety information
N/A.
10. STABILITY AND REACTIVITY
10.1 Reactivity
Stable under recommended transport or storage conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Hazardous reactions will not occur under normal transport or storage conditions. Decomposition may occur on exposure to conditions or materials listed below.
10.4 Conditions to avoid
Heat, moisture.
10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.
10.6 Hazardous decomposition products
In combustion may emit toxic fumes. No known decomposition information.
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
- Acute Toxicity: N/A
- Skin corrosion/irritation: Classified based on available data
- Serious eye damage/irritation: Classified based on available data
- Respiratory or skin sensitization: Classified based on available data
- Germ cell mutagenicity: Classified based on available data
- Carcinogenicity: Classified based on available data
- Reproductive toxicity: Classified based on available data
- Specific target organ toxicity - single exposure: Classified based on available data
- Specific target organ toxicity - repeated exposure: Classified based on available data
- Aspiration hazard: Classified based on available data
Symptoms / Routes of exposure
- Inhalation: There may be shortness of breath with a burning sensation in the throat. Exposure may cause coughing or wheezing.
- Ingestion: There may be soreness and redness of the mouth and throat. There may be difficulty swallowing. Nausea and stomach pain may occur. There may be irritation of the throat.
- Skin: There may be mild irritation at the site of contact. The skin will become dry and flaky. An itchy rash may occur at the site of contact. Irritation or pain may occur at the site of contact.
- Eyes: There may be pain and redness. There may be severe pain. The eyes may water profusely. The vision may become blurred. May cause permanent damage.
- Delayed / Immediate Effects: Immediate effects can be expected after short-term exposure.
Additional Information
- RTECS No: Not available
- Exposure may cause irritation of eyes, mucous membranes, upper respiratory tract and skin.
- To the best of our knowledge, the chemical, physical and toxicological properties have not been fully investigated.
12. ECOLOGICAL INFORMATION
12.1 Toxicity
N/A.
12.2 Persistence and degradability
N/A.
12.3 Bioaccumulative potential
N/A.
12.4 Mobility in soil
N/A.
12.5 Results of PBT and vPvB assessment
N/A.
12.6 Other adverse effects
N/A.
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
- Product: Transfer to a suitable container and arrange for collection by specialized disposal company in accordance with National legislation.
- Contaminated packaging: Dispose of in a regulated landfill site or other method for hazardous or toxic wastes in accordance with National legislation.
14. TRANSPORT INFORMATION
Classified according to the criteria of the UN Model Regulations as reflected in the IMDG Code, ADR, RID and IATA.
14.1 UN-Number
Does not meet the criteria for classification as hazardous for transport.
14.2 UN proper shipping name
Does not meet the criteria for classification as hazardous for transport.
14.3 Transport hazard class(es)
Does not meet the criteria for classification as hazardous for transport.
14.4 Packaging group
Does not meet the criteria for classification as hazardous for transport.
14.5 Environmental hazards
This product is not classified as environmentally hazardous according to the UN Model Regulations, nor a marine pollutant according to the IMDG Code.
14.6 Special precautions for users
N/A.
15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
N/A
California Proposition 65
Not applicable
15.2 Chemical safety assessment
A Chemical Safety Assessment has not been made for this product.
16. OTHER INFORMATION
Revision Date: 2026/07/17
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.