CAS No. 1629063-78-0
Batch:
Purity:98.67
Chemical Structure
Check the
Ibiglustat succinate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(3S)-1-azabicyclo[2.2.2]octan-3-yl] N-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate;(2S)-2-hydroxybutanedioic acid | |
|---|---|---|
| CAS Number | 1629063-78-0 | |
| Molecular Formula |
C20H24FN3O2S.C4H6O5 |
|
| Molecular Weight (MW) | 523.58 | |
| SMILES | CC(C)(NC(=O)OC1CN2CCC1CC2)C3=CSC(=N3)C4=CC=C(F)C=C4.OC(CC(O)=O)C(O)=O | |
| InChIKey | SQXUKOJKIWCALK-AAXLQGCPSA-N |
Ibiglustat succinate (Venglustat succinate) is an orally active, central nervous system-penetrant glucosylceramide synthase inhibitor. By blocking the enzymatic synthesis of glucosylceramide, it prevents downstream glycosphingolipid accumulation and attenuates pathological α-synuclein buildup in the central nervous system. This modulation of the sphingolipid metabolic pathway reduces neurodegenerative substrate burden and improves cognitive deficits in preclinical models of synucleinopathy. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(190.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.