CAS No. 2684292-71-3

Batch: Purity:97.92
Check CoA
IBG1 Chemical Structure
Chemical Structure
Check the IBG1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl 2-[(9S)-7-[4-[4-[[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
CAS Number 2684292-71-3
Molecular Formula

C44H38N8O5S2
Molecular Weight (MW) 822.96
InChIKey HHSZFSOLNUHGMP-BHVANESWSA-N

Ordering Information

Biological Activity

IBG1 is an intramolecular bivalent molecular glue degrader targeting BET bromodomains, promoting proteasomal degradation of BRD4 with a DCof. By bivalently engaging adjacent bromodomains of BRD4 in cis, IBG1 enhances surface complementarity and recruits the CRL4-DCAF16 E3 ubiquitin ligase complex. This induced proximity triggers BRD4 ubiquitination and subsequent degradation, leading to downstream inhibition of cancer cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (60.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.