CAS No. 1323403-33-3
Batch:
Purity:99.75
Chemical Structure
Check the
Iberdomide (CC-220)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione | |
|---|---|---|
| CAS Number | 1323403-33-3 | |
| Molecular Formula |
C25H27N3O5 |
|
| Molecular Weight (MW) | 449.50 | |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5 | |
| InChIKey | IXZOHGPZAQLIBH-NRFANRHFSA-N |
Iberdomide (CC-220) is an oral immunomodulatory compound and potent cereblon modulator that targets the CRL4CRBN E3 ubiquitin ligase complex. It promotes the ubiquitination and proteasomal degradation of zinc-finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). This targeted degradation disrupts downstream oncogenic survival signals, ultimately inducing apoptosis and exhibiting potent antitumor and immunostimulatory activities. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Iberdomide (CC-220) Clinical Trials
- Iberdomide (CC-220) Solubility in DMSO
- Iberdomide (CC-220) Stock Solution
- Iberdomide (CC-220) Storage
- Iberdomide (CC-220) Stability
- Iberdomide (CC-220) Molecular Weight
- Iberdomide (CC-220) SMILES
- Iberdomide (CC-220) Chemical Structure (2D and 3D)
- Iberdomide (CC-220) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.