CAS No. 138926-19-9
| CAS Number | 138926-19-9 | |
|---|---|---|
| Molecular Formula |
C9H23NO7P2.Na.H2O |
|
| Molecular Weight (MW) | 360.23 | |
| SMILES | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)[O-].O.[Na+] |
Ibandronate sodium monohydrate is a nitrogen-containing bisphosphonate that acts as a potent inhibitor of farnesyl pyrophosphate synthase (FPPS) within the mevalonate pathway. By inhibiting FPPS, ibandronate impairs the post-translational prenylation of key signaling GTPases, including Ras, Rho, and Rac. This disruption impairs cytoskeletal organization, ruffled border formation, and cell survival in osteoclasts, ultimately suppressing osteoclast-mediated bone resorption and reducing overall bone turnover. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 72 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 72 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Ibandronate sodium monohydrate Solubility in DMSO
- Ibandronate sodium monohydrate Stock Solution
- Ibandronate sodium monohydrate Storage
- Ibandronate sodium monohydrate Stability
- Ibandronate sodium monohydrate Molecular Weight
- Ibandronate sodium monohydrate SMILES
- Ibandronate sodium monohydrate Chemical Structure (2D and 3D)
- Ibandronate sodium monohydrate SDS｜MSDS