CAS No. 1115270-63-7
Batch:
Purity:99.89
Chemical Structure
Check the
IAXO-102
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4S,5R,6S)-2-(aminomethyl)-6-methoxy-4,5-di(tetradecoxy)oxan-3-ol | |
|---|---|---|
| CAS Number | 1115270-63-7 | |
| Molecular Formula |
C35H71NO5 |
|
| Molecular Weight (MW) | 585.94 | |
| SMILES | CCCCCCCCCCCCCCOC1C(C(OC(C1OCCCCCCCCCCCCCC)OC)CN)O | |
| InChIKey | DJVFNDPRLMVKKO-KJQSSVQNSA-N |
IAXO-102 is a selective small-molecule TLR4 antagonist that directly targets both MD-2 and CD14 accessory co-receptors. By interfering with TLR4 coreceptor signaling complexes, it inhibits downstream MAPK and p65 NF-κB phosphorylation. This pathway inhibition downregulates the expression of TLR4-dependent proinflammatory proteins, attenuates inflammatory cellular responses, and suppresses the development of experimental abdominal aortic aneurysm. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 100 mg/mL |
| DMSO |
15 mg/mL
(25.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.